| Abstract |
| In the present study was to examine the influence of cold stress conditions on memory function in relation with 5-hydroxytryptamine(serotonin, 5-HT), trptophanhydroxylase(TPH) expression and cell proliferation in the hippocampus. For this study, male Sprague-Dawley rats weighing 250 ± 10 g(7 weeks in age) were used. The rats were randomly divided into three groups(n = 10 in each group): the 22℃-control group, the 4℃-3 days group, the 4℃-5 weeks group. The environmental temperature at 22℃ set as the normal conditions, 4℃ was as the cold stress conditions. The present results showed that cold stress conditions shorten latency, representing cold stress disturbed memory function. 5-HT and TPH expressions in the dorsal raphe were increased cold stress. Neurogenesis in the dentate gyrus was increased under cold conditions. The present study revealed that cold stress exerted deteriorative memory function. However, through increasing of 5-HT, TPH and BrdU expression under cold stress conditions did not show memory enhancing effect. |
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| Key Words |
| 인지기능, 신경세포생성, 해마, 세로토닌, 추위 스트레스, Cognitive Function, Serotonin, Cell Proliferation, Cold Stress, Hippocampus |
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